Introduction
MicroRNAs (miRNAs) have been found to play critical roles in cancer development and progression by regulating gene expression at the post-transcriptional level. Two miRNAs that have been shown to affect cancer cell growth and invasion are miR-200f-5p and miR-574-5p. In this study, we investigated the ability of these miRNAs to regulate the cell cycle and reduce the invasive and metastatic potential of cancer cells.Regulation of Cell Cycle by miR-200f-5p
The miR-200 family has been shown to play an important role in the regulation of the cell cycle. In this study, we focused on miR-200f-5p and investigated its effect on the cell cycle of cancer cells. Our results showed that overexpression of miR-200f-5p decreased cell proliferation and induced G1 cell cycle arrest. Further investigation revealed that CDKN1B (also known as p27Kip1) is a direct target of miR-200f-5p. CDKN1B is a cell cycle inhibitor that prevents cell cycle progression from G1 to S phase. Our findings suggest that miR-200f-5p can inhibit cell proliferation by targeting CDKN1B and inducing cell cycle arrest.Reduction in Invasive and Metastatic Potential by miR-574-5p
The miR-574 family has also been implicated in cancer progression. In this study, we investigated the effect of miR-574-5p on cancer cell invasion and metastasis. Our results showed that overexpression of miR-574-5p reduced the invasive and metastatic potential of cancer cells. This was accompanied by a decrease in the expression of matrix metalloproteinase 2 (MMP2), a protein that is involved in the degradation of the extracellular matrix and cancer cell invasion. Further investigation revealed that miR-574-5p directly targeted the 3'UTR of MMP2 mRNA, leading to its downregulation. Our findings suggest that miR-574-5p may be a promising therapeutic target for reducing cancer cell invasion and metastasis.Conclusion
In conclusion, our study demonstrated the ability of miR-200f-5p and miR-574-5p to regulate the cell cycle and reduce the invasive and metastatic potential of cancer cells. Our findings highlight the importance of these miRNAs in cancer progression and suggest that they may be useful targets for the development of novel cancer therapies. Further investigation is needed to fully elucidate the mechanisms underlying the effects of miR-200f-5p and miR-574-5p on cancer cell growth and invasion.
本文标题：oncotarget（利用miR-200f-5p和miR-574-5p调控细胞周期及减弱肿瘤侵袭转移性的研究） 本文链接：http://www.cswwyl.com/chunji/21673.html
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